Archie Moses (Adam Sandler) and Rock Keats (Damon Wayans) were once the best of friends. Now, on opposite sides of the law, the only person who hates them more than they hate each other is drug-trading gangster Frank Colton (James Caan). When Colton attempts to wipe the former buddies out, they are forced to go on the run together. Moses and Keats struggle to forget their feud for long enough to keep each other alive.