Eugene Martone Ralph Macchio is a classically trained guitarist who desperately wants to locate a long-lost blues song. At a Harlem nursing home, Eugene finds Willie Brown (Joe Seneca), a legendary blues man who may be able to help him. Eugene becomes part of the master guitarist's scheme to reclaim his soul from the Devil, which he sold in exchange for musical greatness at a rural crossroads many decades before. Making their way across the Mississippi Delta, the duo meets Frances (Jami Gertz), a runaway who becomes a love interest for Eugene.
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