Junior Doctor Ruby Walker (Amrita Acharia) has fled a cold, grey England after a broken relationship in search of adventure with a glamorous hospital job in tropical South India. Anticipating sunshine, palm trees and picture-perfect beaches, what she doesn't expect is everything she finds at the under-resourced and over-worked Good Karma Hospital. Run by the no-nonsense Doctor Lydia Fonseca (Amanda Redman) - the Good Karma Hospital turns no-one away - locals, ex-pats or tourists. In the company of laidback, beach-bar owner Greg (Neil Morrissey), and tourists-turned residents Maggie and Paul (Phyllis Logan & Philip Jackson), Ruby adjusts to life in India. In Series Two, Dr. Fonseca is still a force to be reckoned with and, determined to kick Ruby out of her comfort zone as a doctor, she pushes too much too soon forcing a snap decision in a crisis that could cost a patient's life. Ruby also connects with her Indian heritage when a lost relative gets in touch. Series Three and Ruby has left the Good Karma Hospital to practise as a GP near her family in rural India. When a medical crisis forces her to return, Ruby must make peace with Lydia and face her colleague Dr. Gabriel Varma (James Krishna Floyd). But through the bonds of family and friendship, will the team weather their biggest challenges yet?