Whether she's investigating the murder of a student environmental activist, the beating death of a boxing champion, an exclusive prep school's deadly college entrance exam cheating scandal, or a celebrity chef's violent end, NYPD Detective Carrie Wells (Poppy Montgomery) relies on her unfailing memory to bring elusive criminals to justice. As she continues dealing with her own problems, including a gambling addiction, Carrie and her partner Al Burns (Dylan Walsh) keep struggling with the remnants of a romance that dates back to high school. While she and her colleagues, including Medical Examiner Joanne Webster (Jane Curtin), confront political cronyism and police corruption standing between them and the truth, Carrie wrestles with the blessing and curse that's made her a potent weapon in the Major Crimes Section's investigative arsenal.