Industrial systems integration is a very diverse topic. It includes the primary technologies of industrial processes, industrial automation systems, industrial networks, industrial systems integration software applications, safety systems, energy systems, and manufacturing management software applications. Therefore, it is difficult to find literature that covers all the areas of industrial systems integration in a coherent manner. In addition, the new manufacturing paradigm of Industry 4.0 has increased the need for experts in industrial systems integration, because it is based on Industrial Internet of Things which is a product of industrial systems integration. This book is a result of lecture notes that the author has developed and refined over many years to cover the theory and practice of industrial systems integration in a coherent manner for those aspiring to become experts in industrial systems integration in particular and Industry 4.0 in general. Principally, the book is written for senior undergraduate and graduate students studying mechanical engineering, manufacturing engineering, electrical engineering, software engineering, automation and smart systems engineering, and computer science. The text is also useful to those in industry who are interested in the implementation of the Industry 4.0 manufacturing paradigm